Evaluation of the Combined Formulation of Parvaquone and Frusemide (Fruvexon) in the Treatment of Experimental Tropical Theileriosis

A combined formulation of parvaquone and frusemide (Fruvexon, Bimeda, Ireland) was evaluated for treatment experimental tropical theileriosis infection of calves. A total of Friesian dairy calves were infected with T. annulata sporozoite stabilate. Following infection with an equivalent of five infected Hyalomma excavatum ticks per calf all animals, developed severe clinical theileriosis. Fruvexon failed to cure or reduce severity of the infection. In contrast, buparvaquone (Butalex, Schering-Plough Animal Health, UK) was highly effective when administered at late stages of infection, and appears to remain the drug of choice against tropical